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This is a phase 3, multicenter study evaluating the safety, tolerability and efficacy of a single dose of study drug injected in the target knee joint of moderately to severely symptomatic osteoarthritis patients. The study is 26 weeks in duration and will enroll male and female patients between the ages of 40 and 80 years of age in general good health.

All study procedures and medication is provided to you at no cost and financial compensated is available for your time and travel to the study site.

All information you provide is stored in a secure site, and cannot be released to any third party without your written and signed authorization.

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Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage on the ends of your bones wears down over time.
Although osteoarthritis can damage any joint in your body, the disorder most commonly affects joints in your hands, knees, hips and spine.

Osteoarthritis symptoms often develop slowly and worsen over time. Signs and symptoms of osteoarthritis include joint pain and/or tenderness, stiffness, loss of flexibility, grating sensation and bone spurs. In osteoarthritis, the slick surface of the cartilage becomes rough. Eventually, if the cartilage wears down completely, you may be left with bone rubbing on bone.

Factors that may increase your risk of osteoarthritis include: older age, sex, obesity, joint injuries, certain occupations, genetics, and bone deformities.

Osteoarthritis symptoms can usually be effectively managed, although the underlying process cannot be reversed. Staying active, maintaining a healthy weight and other treatments may slow progression of the disease and help improve pain and joint function.